Structural change creates friction. Political savvy and commitment to a long-term goal can help you create change that sticks.
The most effective way to shepherd change is to work from both the macro and micro perspective. One should see the overall system as a detached observer and then zoom in to experience the details. Move back and forth between these perspectives to make sure that the design intent is being pushed through all levels of an organization or process.
The best designers can hold both the macro and micro viewpoints in mind simultaneously.